ALZHE IMER ’ S D I S EASE Disruption of the Sleep - Wake Cycle and Diurnal

early brain dysfunction that could be assessed as an outcome measure in response to therapeutic interventions. very mildly impaired humans who are developing AD pathology, the sleep-wake cycle may be a useful indicator of accumulation. If analogous abnormalities in the sleep-wake cycle are present in cognitively normal and β caused by A fluctuation and normal sleep patterns. These findings suggest that changes in the sleep-wake cycle may be β A prevented amyloid plaque formation, as well as maintaining normal circadian β 50%. Actively immunizing mice with A researchers found that the amount of time mice were awake when they were supposed to be asleep increased by accumulation, the β genetic mutations that cause early-onset, autosomal dominant AD. Coincident with increasing A . Similar findings were seen in the cerebrospinal fluid of humans with β plaques sequestering soluble forms of A β fluctuation disappeared with the onset of amyloid plaque deposition, most likely due to insoluble A β . However, A β A occurs in different brain regions in young adult mice that develop accumulation of β show that diurnal fluctuation of A fluctuate in the brain with the sleep-wake cycle. Now, Roh and colleagues β work has shown that soluble forms of A appearance of dementia to initiate therapy earlier as well as to assess the therapeutic effects of new drugs. Previous is accumulating but before the β there are functional and biochemical changes in the brain that are present when A and is already very substantial by the time memory and thinking problems begin. It is critical to determine whether accumulation in amyloid plaques begins about 10 to 15 years before cognitive decline β Alzheimer's disease (AD). A ) peptide is a key event in the pathogenesis of β -amyloid (A β The accumulation in the brain of the neurotoxic Don't Let Amyloid Keep You Awake at Night